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GO:0005085: guanyl-nucleotide exchange factor activity (Molecular function)

"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]


There are 313 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_56 Saccharomyces cerevisiae 3.08 % 0.008053 0.03776
Cluster_12 Saccharomyces cerevisiae 6.67 % 6e-06 0.001045
Cluster_48 Saccharomyces cerevisiae 3.45 % 0.000725 0.027139
Cluster_24 Aspergillus fumigatus 2.38 % 8e-06 6.6e-05
Cluster_54 Aspergillus fumigatus 2.16 % 0.000114 0.0028
Cluster_38 Aspergillus nidulans 2.86 % 0.0 1.5e-05
Cluster_71 Aspergillus nidulans 3.33 % 0.000255 0.006091
Cluster_128 Aspergillus niger 2.44 % 0.003414 0.03024
Cluster_65 Aspergillus niger 3.64 % 0.0 1e-06
Cluster_54 Coprinopsis cinerea 1.97 % 0.005628 0.043901
Cluster_65 Coprinopsis cinerea 1.81 % 0.007179 0.03299
Cluster_87 Coprinopsis cinerea 7.25 % 1e-06 6.5e-05
Cluster_18 Cryptococcus neoformans 4.72 % 7.3e-05 0.001972
Cluster_28 Dichomitus squalens 2.38 % 0.000576 0.004411
Cluster_59 Fusarium graminearum 6.08 % 0.0 0.0
Cluster_18 Neurospora crassa 3.65 % 0.0 1e-06
Cluster_61 Neurospora crassa 12.07 % 0.0 0.0
Cluster_3 Postia placenta 2.53 % 5e-06 0.000107
Cluster_20 Puccinia striiformis 2.24 % 0.001365 0.015382
Cluster_95 Puccinia striiformis 2.74 % 0.006444 0.038384
Cluster_119 Pyricularia oryzae 5.75 % 0.0 1e-06
Cluster_53 Schizosaccharomyces pombe 5.17 % 0.000686 0.016084
Cluster_45 Schizosaccharomyces pombe 5.0 % 0.000758 0.0447
Cluster_16 Trichoderma reesei 2.46 % 9e-06 0.000125
Cluster_38 Trichoderma reesei 4.17 % 0.000162 0.003071
Cluster_26 Sclerotinia sclerotiorum 2.82 % 0.002535 0.012015
Cluster_86 Sclerotinia sclerotiorum 2.28 % 2e-06 2.8e-05
Sequences (313) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms