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GO:0003700: DNA-binding transcription factor activity (Molecular function)

"A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]


There are 2685 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_23 Saccharomyces cerevisiae 7.47 % 0.0 6e-06
Cluster_14 Saccharomyces cerevisiae 6.94 % 0.00191 0.045563
Cluster_37 Saccharomyces cerevisiae 8.47 % 0.000775 0.003701
Cluster_34 Aspergillus fumigatus 9.4 % 6.9e-05 0.000431
Cluster_97 Aspergillus fumigatus 9.8 % 0.005852 0.024457
Cluster_95 Aspergillus fumigatus 9.52 % 0.002991 0.026199
Cluster_84 Aspergillus fumigatus 15.22 % 7.2e-05 0.001485
Cluster_111 Aspergillus nidulans 20.45 % 4e-06 2.5e-05
Cluster_22 Aspergillus nidulans 19.15 % 0.0 0.0
Cluster_109 Aspergillus nidulans 13.64 % 0.001759 0.025205
Cluster_88 Aspergillus nidulans 10.91 % 0.005506 0.032837
Cluster_45 Aspergillus nidulans 10.0 % 0.00841 0.043577
Cluster_30 Aspergillus nidulans 11.01 % 8.8e-05 0.002484
Cluster_57 Aspergillus niger 9.8 % 0.004667 0.023333
Cluster_95 Aspergillus niger 7.58 % 0.013693 0.029374
Cluster_78 Aspergillus niger 8.64 % 0.001777 0.005973
Cluster_112 Aspergillus niger 8.9 % 1.6e-05 0.000145
Cluster_15 Aspergillus niger 5.67 % 0.003227 0.039338
Cluster_124 Aspergillus niger 14.29 % 2e-06 2.1e-05
Cluster_115 Aspergillus niger 7.59 % 0.000299 0.00135
Cluster_119 Aspergillus niger 7.41 % 0.007947 0.037837
Cluster_57 Candida albicans 15.66 % 0.0 0.0
Cluster_42 Candida albicans 4.74 % 0.001375 0.027588
Cluster_41 Cryptococcus neoformans 10.23 % 2.2e-05 0.005079
Cluster_76 Cryptococcus neoformans 11.32 % 0.000313 0.009293
Cluster_38 Cryptococcus neoformans 7.89 % 0.002143 0.021112
Cluster_120 Fusarium graminearum 8.16 % 0.014947 0.037839
Cluster_75 Fusarium graminearum 14.29 % 0.0 0.0
Cluster_96 Fusarium graminearum 13.27 % 0.0 0.0
Cluster_70 Fusarium graminearum 8.64 % 0.000993 0.013367
Cluster_125 Fusarium graminearum 9.68 % 0.001264 0.018285
Cluster_52 Komagataella phaffii 6.03 % 0.001513 0.034664
Cluster_49 Neurospora crassa 14.81 % 1e-06 0.00021
Cluster_50 Neurospora crassa 3.93 % 0.014619 0.04873
Cluster_20 Neurospora crassa 8.33 % 0.001693 0.018756
Cluster_159 Neurospora crassa 100.0 % 0.000207 0.000957
Cluster_316 Puccinia striiformis 50.0 % 0.006352 0.011209
Cluster_93 Puccinia striiformis 3.66 % 0.002243 0.016185
Cluster_20 Puccinia striiformis 2.99 % 0.000855 0.010888
Cluster_268 Puccinia striiformis 33.33 % 0.009513 0.042809
Cluster_4 Pyricularia oryzae 7.02 % 9e-06 0.000134
Cluster_14 Yarrowia lipolytica 4.96 % 0.000782 0.024945
Cluster_53 Schizosaccharomyces pombe 6.9 % 0.001807 0.014567
Cluster_75 Trichoderma reesei 9.41 % 0.000447 0.005339
Cluster_34 Trichoderma reesei 6.38 % 0.003218 0.035399
Cluster_88 Trichoderma reesei 12.0 % 0.000644 0.00256
Cluster_24 Trichoderma reesei 10.91 % 4e-06 9e-05
Cluster_59 Trichoderma reesei 8.06 % 0.010278 0.041278
Cluster_86 Sclerotinia sclerotiorum 4.57 % 5e-06 6.2e-05
Sequences (2685) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms