EAU92936

Description : DNA topoisomerase II

Gene families : OG_03_0001188 (OF) Phylogenetic Tree(s): OG0001188_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: EAU92936
Cluster	HCCA: Cluster_47

Target	Alias	Description	ECC score	Gene Family Method
AOA68730	No alias	DNA topoisomerase, type IIA, subunit B, domain 2	0.05	OF
CAG81413	No alias	TOPRIM domain	0.07	OF
CAK96636	No alias	DNA gyrase/topoisomerase IV, subunit A	0.07	OF
CBF81963	No alias	DNA topoisomerase 2	0.07	OF
EAL89207	No alias	DNA topoisomerase II	0.07	OF
EAU87295	No alias	DNA topoisomerase II	0.01	OF
EDN97002	No alias	TOPRIM domain	0.06	OF
EGR51999	No alias	Histidine kinase/HSP90-like ATPase	0.02	OF
EJF58805	No alias	DNA gyrase/topoisomerase IV, subunit A	0.08	OF
ESA42913	No alias	C-terminal associated domain of TOPRIM	0.01	OF
ESU16429	No alias	DNA topoisomerase 2	0.06	OF
KHC76731	No alias	DNA topoisomerase 2;"DNA gyrase/topoisomerase IV,...	0.08	OF
MGG_06162T0	No alias	DNA topoisomerase 2 [Source:UniProtKB/TrEMBL;Acc:G4MZZ7]	0.04	OF
SPBC1A4.03c.1	No alias	DNA topoisomerase II [Source:PomBase;Acc:SPBC1A4.03c]	0.05	OF
YNL088W	No alias	Topoisomerase II; relieves torsional strain in DNA by...	0.04	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	None	Extended
MF	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
MF	GO:0008094	DNA-dependent ATPase activity	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR013506	Topo_IIA_bsu_dom2	322	489
IPR031660	TOPRIM_C	634	760
IPR003594	HATPase_C	134	280
IPR002205	Topo_IIA_A/C	762	1231
IPR006171	TOPRIM_domain	520	618

External Links

No external refs found!

EAU92936

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation