GO:0003918: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (Molecular function)

"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]


There are 22 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_41 Saccharomyces cerevisiae 1.85 % 0.008182 0.028448
Cluster_18 Aspergillus nidulans 0.59 % 0.016043 0.034294
Cluster_89 Aspergillus niger 1.19 % 0.006025 0.016624
Cluster_6 Cryptococcus neoformans 2.94 % 7.4e-05 0.00837
Cluster_22 Komagataella phaffii 1.3 % 0.015205 0.04974
Cluster_128 Neurospora crassa 50.0 % 0.00037 0.020354
Cluster_31 Puccinia striiformis 0.64 % 0.010338 0.028606
Cluster_10 Pyricularia oryzae 0.91 % 0.008624 0.02143
Cluster_54 Trichoderma reesei 0.83 % 0.013275 0.040979
Cluster_26 Sclerotinia sclerotiorum 1.41 % 0.006978 0.022046
Sequences (22) (download table)

InterPro Domains

GO Terms

Family Terms