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YMR089C


Description : Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation [Source:SGD;Acc:S000004695]


Gene families : OG_03_0001646 (OF) Phylogenetic Tree(s): OG0001646_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YMR089C
Cluster HCCA: Cluster_33

Target Alias Description ECC score Gene Family Method Actions
AFR93532 No alias AFG3 family protein;ATPase family associated with... 0.04 OF
AOA65486 No alias ATPase, AAA-type, core 0.09 OF
AOA69461 No alias Peptidase M41 0.12 OF
CAG82648 No alias Peptidase M41 0.14 OF
CAG83880 No alias ATPase, AAA-type, core 0.09 OF
CAK39542 No alias FtsH Extracellular 0.04 OF
CBF77262 No alias mitochondrial inner membrane AAA protease Yta12, putative 0.09 OF
EAA27520 No alias AAA ATPase, AAA+ lid domain 0.04 OF
EAL87365 No alias mitochondrial inner membrane AAA protease Yta12, putative 0.12 OF
EAU92673 No alias Peptidase M41AAA ATPase, AAA+ lid domainATPase,... 0.07 OF
EDN91150 No alias Peptidase M41 0.12 OF
EGR52562 No alias Peptidase M41 0.04 OF
KHC80121 No alias ATP-dependent metallopeptidase HflB;ATPase family... 0.13 OF
KHC81146 No alias ATP-dependent metallopeptidase HflB;FtsH... 0.12 OF
MGG_07441T0 No alias Paraplegin [Source:UniProtKB/TrEMBL;Acc:G4N151] 0.02 OF
SPBC543.09.1 No alias mitochondrial m-AAA protease Yta12 (predicted)... 0.1 OF

Type GO Term Name Evidence Source
MF GO:0004222 metalloendopeptidase activity IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0006508 proteolysis IEA Interproscan
MF GO:0008270 zinc ion binding IEA Interproscan
CC GO:0016021 integral component of membrane IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR011546 Pept_M41_FtsH_extracell 184 277
IPR003959 ATPase_AAA_core 385 517
IPR041569 AAA_lid_3 546 585
IPR000642 Peptidase_M41 601 781
No external refs found!