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GO:0004222: metalloendopeptidase activity (Molecular function)

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]


There are 209 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_33 Saccharomyces cerevisiae 3.23 % 0.002344 0.012601
Cluster_78 Aspergillus niger 2.47 % 0.001456 0.005058
Cluster_20 Candida albicans 2.6 % 0.003827 0.02784
Cluster_39 Candida albicans 2.06 % 0.006013 0.02628
Cluster_14 Dichomitus squalens 2.86 % 0.003996 0.028769
Cluster_6 Komagataella phaffii 5.81 % 1e-06 2.9e-05
Cluster_66 Neurospora crassa 3.77 % 0.001035 0.01346
Cluster_55 Puccinia striiformis 1.89 % 0.024333 0.0409
Cluster_20 Yarrowia lipolytica 2.47 % 0.005299 0.045574
Cluster_13 Yarrowia lipolytica 2.23 % 6.5e-05 0.0022
Cluster_59 Sclerotinia sclerotiorum 1.27 % 0.004722 0.017078
Sequences (209) (download table)

InterPro Domains

GO Terms

Family Terms