YPL149W

Description : Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner [Source:SGD;Acc:S000006070]

Gene families : OG_03_0002865 (OF) Phylogenetic Tree(s): OG0002865_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YPL149W
Cluster	HCCA: Cluster_65

Type	GO Term	Name	Evidence	Source
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005737	cytoplasm	IEA	Interproscan
BP	GO:0006914	autophagy	IEA	Interproscan
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
BP	GO:0061919	process utilizing autophagic mechanism	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR007239	Atg5	83	281

External Links

No external refs found!

YPL149W

Expression Profile

Co-expression Networks

Functional Annotation