YOR335C

Description : Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis [Source:SGD;Acc:S000005862]

Gene families : OG_03_0003847 (OF) Phylogenetic Tree(s): OG0003847_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YOR335C
Cluster	HCCA: Cluster_8

Target	Alias	Description	ECC score	Gene Family Method
AFR96040	No alias	alanine-tRNA ligase;DHHA1 domain;Threonyl and Alanyl...	0.03	OF
AOA68523	No alias	Alanyl-tRNA synthetase, class IIc, N-terminal	0.04	OF
CAG82710	No alias	Alanyl-tRNA synthetase, class IIc, N-terminal	0.1	OF
CAK47129	No alias	Threonyl and Alanyl tRNA synthetase second additional domain	0.06	OF
CBF84773	No alias	alanyl-tRNA synthetase, putative	0.1	OF
EAL85157	No alias	alanyl-tRNA synthetase, putative	0.06	OF
EAU91282	No alias	tRNA synthetase class II	0.06	OF
EDO03520	No alias	Alanyl-tRNA synthetase, class IIc, N-terminal	0.05	OF
EGR47532	No alias	Threonyl/alanyl tRNA synthetase, SAD	0.08	OF
ESU06156	No alias	alanyl-tRNA synthetase	0.07	OF
KHC73506	No alias	alanyl-tRNA synthetase;DHHA1 domain;tRNA synthetases...	0.23	OF
POW15293	No alias	Alanyl-tRNA synthetase, class IIc, N-terminal;DHHA1...	0.03	OF
SPAC23C11.09.1	No alias	mitochondrial and cytoplasmic alanine-tRNA ligase Ala1...	0.2	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEA	Interproscan
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	IEA	Interproscan
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEA	Interproscan
MF	GO:0004813	alanine-tRNA ligase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006399	tRNA metabolic process	None	Extended
BP	GO:0006418	tRNA aminoacylation for protein translation	None	Extended
BP	GO:0006419	alanyl-tRNA aminoacylation	IEA	Interproscan
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016070	RNA metabolic process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034660	ncRNA metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0043038	amino acid activation	None	Extended
BP	GO:0043039	tRNA aminoacylation	IEA	Interproscan
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140098	catalytic activity, acting on RNA	None	Extended
MF	GO:0140101	catalytic activity, acting on a tRNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR003156	DHHA1_dom	805	951
IPR012947	tRNA_SAD	690	749
IPR018164	Ala-tRNA-synth_IIc_N	13	590

External Links

No external refs found!

YOR335C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation