Description : Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication [Source:SGD;Acc:S000005634]

Gene families : OG_03_0001612 (OF) Phylogenetic Tree(s): OG0001612_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YOR108W
Cluster HCCA: Cluster_7

Target Alias Description ECC score Gene Family Method Actions
AFR98921 No alias 2-isopropylmalate synthase;LeuA allosteric... 0.04 OF
AOA67035 No alias Pyruvate carboxyltransferase 0.05 OF
CAK37362 No alias HMGL-like 0.06 OF
CBF88679 No alias 2-isopropylmalate synthase 0.1 OF
EAL90831 No alias 2-isopropylmalate synthase 0.07 OF
EAU88704 No alias 2-isopropylmalate synthase 0.02 OF
EGR47294 No alias 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 0.03 OF
ESU12745 No alias 2-isopropylmalate synthase 0.07 OF
MGG_13485T0 No alias 2-isopropylmalate synthase [Source:UniProtKB/TrEMBL;Acc:G4N6T3] 0.05 OF
SPBC3E7.16c.1 No alias 2-isopropylmalate synthase Leu3 [Source:PomBase;Acc:SPBC3E7.16c] 0.05 OF

Type GO Term Name Evidence Source
MF GO:0003824 catalytic activity IEA Interproscan
MF GO:0003852 2-isopropylmalate synthase activity IEA Interproscan
BP GO:0009098 leucine biosynthetic process IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR000891 PYR_CT 60 341
IPR013709 2-isopropylmalate_synth_dimer 455 594
No external refs found!