Description : DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome [Source:SGD;Acc:S000005531]

Gene families : OG_03_0002010 (OF) Phylogenetic Tree(s): OG0002010_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YOR005C
Cluster HCCA: Cluster_53

Target Alias Description ECC score Gene Family Method Actions
AOA69231 No alias DNA ligase, ATP-dependent, central 0.05 OF
CAG81303 No alias DNA ligase, ATP-dependent, C-terminal 0.03 OF
ESU08977 No alias DNA ligase, ATP-dependent, C-terminal 0.01 OF
SPCC1183.05c.1 No alias DNA repair ligase Lig4 [Source:PomBase;Acc:SPCC1183.05c] 0.03 OF

Type GO Term Name Evidence Source
MF GO:0003677 DNA binding IEA Interproscan
MF GO:0003910 DNA ligase (ATP) activity IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0006281 DNA repair IEA Interproscan
BP GO:0006310 DNA recombination IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR012310 DNA_ligase_ATP-dep_cent 256 466
IPR012308 DNA_ligase_ATP-dep_N 20 214
IPR001357 BRCT_dom 683 767
IPR001357 BRCT_dom 839 928
No external refs found!