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  5. YML130C

YML130C


Description : Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L [Source:SGD;Acc:S000004599]


Gene families : OG_03_0002639 (OF) Phylogenetic Tree(s): OG0002639_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood HRR: YML130C
Cluster HCCA: Cluster_30

Target Alias Description ECC score Gene Family Method Actions
AFR96403 No alias endoplasmic oxidoreductin 1;Endoplasmic Reticulum... 0.07 OF
CBF85011 No alias oxidoreductin 0.02 OF

Type GO Term Name Evidence Source
MF GO:0003756 protein disulfide isomerase activity IEA Interproscan
CC GO:0005783 endoplasmic reticulum IEA Interproscan
MF GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA Interproscan
BP GO:0055114 oxidation-reduction process IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR007266 Ero1 66 413
No external refs found!