Description : Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability [Source:SGD;Acc:S000001795]
Gene families : OG_03_0001556 (OF) Phylogenetic Tree(s): OG0001556_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YKR087C | |
Cluster | HCCA: Cluster_60 |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0004222 | metalloendopeptidase activity | IEA | Interproscan |
BP | GO:0006508 | proteolysis | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR001915 | Peptidase_M48 | 157 | 319 |
No external refs found! |