Description : Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves both isoprenylated and non-prenylated oligopeptides; contains multiple transmembrane spans; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and can complement yeast null mutant [Source:SGD;Acc:S000003878]

Gene families : OG_03_0002467 (OF) Phylogenetic Tree(s): OG0002467_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YJR117W
Cluster HCCA: Cluster_39

Target Alias Description ECC score Gene Family Method Actions
AOA67013 No alias Peptidase M48 0.03 OF
CAL00682 No alias Peptidase family M48 0.09 OF
CBF77446 No alias CaaX prenyl protease 0.06 OF
EAA32128 No alias Peptidase M48 0.05 OF
EAU83492 No alias metalloendopeptidase 0.03 OF
EGR49342 No alias CAAX prenyl protease 1, N-terminal 0.07 OF
EJF62033 No alias Peptidase family M48 0.06 OF
ESU11933 No alias Peptidase M48 0.05 OF
KHC77979 No alias STE24 endopeptidase;"CAAX prenyl protease N-terminal,... 0.05 OF
POW05088 No alias CAAX prenyl protease 1, N-terminal;Peptidase M48 0.02 OF

Type GO Term Name Evidence Source
MF GO:0004222 metalloendopeptidase activity IEA Interproscan
BP GO:0006508 proteolysis IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001915 Peptidase_M48 226 446
IPR032456 Peptidase_M48_N 37 223
No external refs found!