Description : Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA [Source:SGD;Acc:S000003830]

Gene families : OG_03_0000875 (OF) Phylogenetic Tree(s): OG0000875_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YJR069C
Cluster HCCA: Cluster_13

Target Alias Description ECC score Gene Family Method Actions
KHC75276 No alias RdgB/HAM1 family non-canonical purine NTP... 0.03 OF

Type GO Term Name Evidence Source
BP GO:0009143 nucleoside triphosphate catabolic process IEA Interproscan
MF GO:0047429 nucleoside-triphosphate diphosphatase activity IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR002637 Ham1p-like 6 190
No external refs found!