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Expression profile for YJR069C (YJR069C)

Description : Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA [Source:SGD;Acc:S000003830]

Sample enrichment: synthetic complete med,20C,WT (SPM: 0.35, entropy: 3.28, tau: 0.65)
Perturbation specificity: YPDA (SPM: 0.47, entropy: 2.69, tau: 0.45)