YGR264C

Description : Methionyl-tRNA synthetase; forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs; mutations in human ortholog MARS are associated with pediatric pulmonary alveolar proteinosis [Source:SGD;Acc:S000003496]

Gene families : OG_03_0003447 (OF) Phylogenetic Tree(s): OG0003447_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YGR264C
Cluster	HCCA: Cluster_8

Target	Alias	Description	ECC score	Gene Family Method
AFR94837	No alias	methionine-tRNA ligase;tRNA synthetases class I (M)	0.06	OF
CAG78837	No alias	Methionyl/Leucyl tRNA synthetase	0.08	OF
CAK45203	No alias	tRNA synthetases class I (M)	0.1	OF
CBF87610	No alias	methionyl-tRNA synthetase	0.14	OF
EAA35402	No alias	Methionyl/Leucyl tRNA synthetase	0.11	OF
EAL90230	No alias	methionyl-tRNA synthetase	0.12	OF
EAU85609	No alias	methionyl tRNA synthetase	0.02	OF
EED81599	No alias	Methionyl/Leucyl tRNA synthetase	0.03	OF
EGR44409	No alias	Methionyl/Leucyl tRNA synthetase	0.08	OF
ESU14708	No alias	methionyl-tRNA synthetase	0.1	OF
KHC75362	No alias	methionine-tRNA ligase;tRNA synthetases class I...	0.13	OF
MGG_01046T0	No alias	Methionyl-tRNA synthetase [Source:UniProtKB/TrEMBL;Acc:G4NCR9]	0.1	OF
SPBC17A3.04c.1	No alias	cytoplasmic methionine-tRNA ligase Mrs1 (predicted)...	0.15	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEA	Interproscan
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006399	tRNA metabolic process	None	Extended
BP	GO:0006418	tRNA aminoacylation for protein translation	IEA	Interproscan
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016070	RNA metabolic process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034660	ncRNA metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0043038	amino acid activation	None	Extended
BP	GO:0043039	tRNA aminoacylation	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140098	catalytic activity, acting on RNA	None	Extended
MF	GO:0140101	catalytic activity, acting on a tRNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR018285	Met-tRNA-synth_N	11	132
IPR015413	Methionyl/Leucyl_tRNA_Synth	198	589

External Links

No external refs found!

YGR264C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation