YGR204W

Description : Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine [Source:SGD;Acc:S000003436]

Gene families : OG_03_0000788 (OF) Phylogenetic Tree(s): OG0000788_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YGR204W
Cluster	HCCA: Cluster_7

Target	Alias	Description	ECC score	Gene Family Method
AFR96762	No alias	methylenetetrahydrofolate dehydrogenase...	0.04	OF
AOA65937	No alias	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	0.03	OF
AOA69596	No alias	Formate-tetrahydrofolate ligase, FTHFS	0.04	OF
CAG78877	No alias	Tetrahydrofolate dehydrogenase/cyclohydrolase,...	0.15	OF
CAG78978	No alias	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	0.12	OF
EAL92712	No alias	C1 tetrahydrofolate synthase, putative	0.02	OF
EDO01420	No alias	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	0.03	OF
EFI28376	No alias	C-1-tetrahydrofolate synthase	0.05	OF
EGR50859	No alias	Formate-tetrahydrofolate ligase, FTHFS	0.1	OF
ESA42228	No alias	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	0.09	OF
ESA42229	No alias	Formate-tetrahydrofolate ligase, FTHFS	0.06	OF
ESU16958	No alias	C-1-tetrahydrofolate synthase	0.07	OF
KHC70553	No alias	hypothetical protein;"Tetrahydrofolate...	0.07	OF
KHC70991	No alias	hypothetical protein;"Tetrahydrofolate...	0.17	OF
MGG_01014T0	No alias	C-1-tetrahydrofolate synthase...	0.05	OF
POW11496	No alias	Formate-tetrahydrofolate ligase, FTHFS;Tetrahydrofolate...	0.03	OF
SPBC839.16.1	No alias	C1-5,6,7,8-tetrahydrofolate (THF) synthase,...	0.05	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004329	formate-tetrahydrofolate ligase activity	IEA	Interproscan
MF	GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	None	Extended
MF	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	None	Extended
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016879	ligase activity, forming carbon-nitrogen bonds	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	Interproscan
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR020631	THF_DH/CycHdrlase_NAD-bd_dom	126	299
IPR020630	THF_DH/CycHdrlase_cat_dom	5	122
IPR000559	Formate_THF_ligase	322	946

External Links

No external refs found!

YGR204W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation