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YER017C


Description : Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant [Source:SGD;Acc:S000000819]


Gene families : OG_03_0001646 (OF) Phylogenetic Tree(s): OG0001646_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YER017C
Cluster HCCA: Cluster_68

Target Alias Description ECC score Gene Family Method Actions
CAG82648 No alias Peptidase M41 0.04 OF
CAG83880 No alias ATPase, AAA-type, core 0.03 OF
EAU92673 No alias Peptidase M41AAA ATPase, AAA+ lid domainATPase,... 0.04 OF
EGR52562 No alias Peptidase M41 0.02 OF
KHC80121 No alias ATP-dependent metallopeptidase HflB;ATPase family... 0.05 OF

Type GO Term Name Evidence Source
MF GO:0004222 metalloendopeptidase activity IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0006508 proteolysis IEA Interproscan
MF GO:0008270 zinc ion binding IEA Interproscan
CC GO:0016021 integral component of membrane IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR041569 AAA_lid_3 492 530
IPR000642 Peptidase_M41 545 727
IPR011546 Pept_M41_FtsH_extracell 124 211
IPR003959 ATPase_AAA_core 325 458
No external refs found!