AFR96922

Description : DNA topoisomerase I;Eukaryotic DNA topoisomerase I, catalytic core;C-terminal topoisomerase domain;Eukaryotic DNA topoisomerase I, DNA binding fragment

Gene families : OG_03_0002666 (OF) Phylogenetic Tree(s): OG0002666_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AFR96922
Cluster	HCCA: Cluster_38

Target	Alias	Description	ECC score	Gene Family Method
CAG81506	No alias	Topoisomerase I C-terminal domain	0.07	OF
EAL88062	No alias	topoisomerase I	0.05	OF
EJF57661	No alias	Eukaryotic DNA topoisomerase I, DNA binding fragment	0.02	OF
ESA44117	No alias	DNA topoisomerase I, catalytic core, eukaryotic-type	0.02	OF
MGG_09917T0	No alias	DNA topoisomerase 1 [Source:UniProtKB/TrEMBL;Acc:G4MR71]	0.05	OF
POW15356	No alias	DNA topoisomerase I, catalytic core,...	0.04	OF
YOL006C	No alias	Topoisomerase I; nuclear enzyme that relieves torsional...	0.04	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	None	Extended
MF	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR013500	TopoI_cat_euk	528	750
IPR025834	TopoI_C_dom	861	931
IPR008336	TopoI_DNA-bd_euk	308	524

External Links

No external refs found!

AFR96922

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation