YOR244W

Description : Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation [Source:SGD;Acc:S000005770]

Gene families : OG_03_0000399 (OF) Phylogenetic Tree(s): OG0000399_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YOR244W
Cluster	HCCA: Cluster_68

Target	Alias	Description	ECC score	Gene Family Method
EAL89699	No alias	histone acetyltransferase, putative	0.02	OF
ESU08867	No alias	histone acetyltransferase E	0.03	OF
MGG_04133T0	No alias	Histone acetyltransferase esa-1...	0.03	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004402	histone acetyltransferase activity	IEA	Interproscan
BP	GO:0006325	chromatin organization	None	Extended
BP	GO:0006355	regulation of transcription, DNA-templated	IEA	Interproscan
BP	GO:0006464	cellular protein modification process	None	Extended
BP	GO:0006473	protein acetylation	None	Extended
BP	GO:0006475	internal protein amino acid acetylation	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008080	N-acetyltransferase activity	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016407	acetyltransferase activity	None	Extended
MF	GO:0016410	N-acyltransferase activity	None	Extended
BP	GO:0016569	covalent chromatin modification	None	Extended
BP	GO:0016570	histone modification	None	Extended
BP	GO:0016573	histone acetylation	IEA	Interproscan
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016746	transferase activity, transferring acyl groups	None	Extended
MF	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	None	Extended
BP	GO:0018193	peptidyl-amino acid modification	None	Extended
BP	GO:0018205	peptidyl-lysine modification	None	Extended
BP	GO:0018393	internal peptidyl-lysine acetylation	None	Extended
BP	GO:0018394	peptidyl-lysine acetylation	None	Extended
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
MF	GO:0034212	peptide N-acetyltransferase activity	None	Extended
BP	GO:0036211	protein modification process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0043543	protein acylation	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044267	cellular protein metabolic process	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051252	regulation of RNA metabolic process	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
MF	GO:0061733	peptide-lysine-N-acetyltransferase activity	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1903506	regulation of nucleic acid-templated transcription	None	Extended
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	None	Extended
BP	GO:2001141	regulation of RNA biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR025995	Tudor-knot	22	74
IPR040706	Zf-MYST	164	218
IPR002717	HAT_MYST-type	223	400

External Links

No external refs found!

YOR244W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation