Description : Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant [Source:SGD;Acc:S000005752]

Gene families : OG_03_0001901 (OF) Phylogenetic Tree(s): OG0001901_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YOR226C
Cluster HCCA: Cluster_19

Target Alias Description ECC score Gene Family Method Actions
CAK38574 No alias NifU-like N terminal domain 0.03 OF
EAL90111 No alias iron-sulfur cofactor synthesis protein (Isu1), putative 0.02 OF
KHC71860 No alias iron sulfur cluster assembly protein 1,... 0.07 OF
SPAC227.13c.1 No alias mitochondrial iron-sulfur cluster assembly scaffold... 0.09 OF

Type GO Term Name Evidence Source
MF GO:0005506 iron ion binding IEA Interproscan
BP GO:0016226 iron-sulfur cluster assembly IEA Interproscan
MF GO:0051536 iron-sulfur cluster binding IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR002871 NIF_FeS_clus_asmbl_NifU_N 27 150
No external refs found!