Description : Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant [Source:SGD;Acc:S000005752]
Gene families : OG_03_0001901 (OF) Phylogenetic Tree(s): OG0001901_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YOR226C | |
Cluster | HCCA: Cluster_19 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
CAK38574 | No alias | NifU-like N terminal domain | 0.03 | OF | |
EAL90111 | No alias | iron-sulfur cofactor synthesis protein (Isu1), putative | 0.02 | OF | |
KHC71860 | No alias | iron sulfur cluster assembly protein 1,... | 0.07 | OF | |
SPAC227.13c.1 | No alias | mitochondrial iron-sulfur cluster assembly scaffold... | 0.09 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0005506 | iron ion binding | IEA | Interproscan |
BP | GO:0016226 | iron-sulfur cluster assembly | IEA | Interproscan |
MF | GO:0051536 | iron-sulfur cluster binding | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR002871 | NIF_FeS_clus_asmbl_NifU_N | 27 | 150 |
No external refs found! |