YOL090W

Description : Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP [Source:SGD;Acc:S000005450]

Gene families : OG_03_0002636 (OF) Phylogenetic Tree(s): OG0002636_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YOL090W
Cluster	HCCA: Cluster_41

Target	Alias	Description	ECC score	Gene Family Method
AFR92901	No alias	DNA mismatch repair protein MSH2;MutS domain III;MutS...	0.03	OF
AOA66859	No alias	DNA mismatch repair protein MutS, core	0.06	OF
CAG77608	No alias	DNA mismatch repair protein MutS, clamp	0.09	OF
CBF76294	No alias	DNA mismatch repair protein Msh2, putative	0.09	OF
EAA30407	No alias	DNA mismatch repair protein MutS, clamp	0.12	OF
EAL92596	No alias	DNA mismatch repair protein Msh2, putative	0.09	OF
EED79742	No alias	DNA mismatch repair protein MutS, connector domain	0.02	OF
EGR49093	No alias	DNA mismatch repair protein MutS, clamp	0.12	OF
ESU12411	No alias	DNA mismatch repair protein msh-2	0.06	OF
KHC76783	No alias	DNA mismatch repair protein MSH2;MutS domain III;MutS...	0.07	OF
MGG_00879T0	No alias	DNA mismatch repair protein msh-2...	0.08	OF
POW13927	No alias	DNA mismatch repair protein MutS, core;DNA mismatch...	0.02	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	None	Extended
MF	GO:0003690	double-stranded DNA binding	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006298	mismatch repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0030983	mismatched DNA binding	IEA	Interproscan
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR007695	DNA_mismatch_repair_MutS-lik_N	19	114
IPR007696	DNA_mismatch_repair_MutS_core	301	627
IPR007861	DNA_mismatch_repair_MutS_clamp	491	586
IPR000432	DNA_mismatch_repair_MutS_C	684	879
IPR007860	DNA_mmatch_repair_MutS_con_dom	141	285

External Links

No external refs found!

YOL090W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation