Description : Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000005217]
Gene families : OG_03_0002160 (OF) Phylogenetic Tree(s): OG0002160_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | HRR: YNL273W | |
| Cluster | HCCA: Cluster_41 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| AFR96264 | No alias | topoisomerase 1-associated factor 1;Timeless protein C... | 0.1 | OF | |
| AOA67102 | No alias | Timeless protein | 0.09 | OF | |
| CAG82801 | No alias | Timeless, C-terminal | 0.08 | OF | |
| CAK41843 | No alias | Timeless protein C terminal region | 0.06 | OF | |
| CBF79271 | No alias | hypothetical protein similar to drug resistance protein MdrA | 0.03 | OF | |
| EAA29535 | No alias | Timeless, C-terminal | 0.13 | OF | |
| EAL84586 | No alias | DNA repair protein (Tof1), putative | 0.09 | OF | |
| EDN91270 | No alias | Timeless, C-terminal | 0.04 | OF | |
| EED44801 | No alias | DNA repair protein (Tof1), putative | 0.03 | OF | |
| EED81354 | No alias | Timeless, C-terminal | 0.02 | OF | |
| EGR53100 | No alias | Timeless protein | 0.11 | OF | |
| EJF59953 | No alias | Timeless protein | 0.02 | OF | |
| ESU12961 | No alias | Timeless protein | 0.09 | OF | |
| KHC75050 | No alias | topoisomerase 1-associated factor 1;Timeless protein | 0.12 | OF | |
| MGG_03991T0 | No alias | Topoisomerase 1-associated factor 1... | 0.12 | OF | |
| SPBC216.06c.1 | No alias | replication fork protection complex subunit Swi1... | 0.11 | OF |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No GO annotation available for this sequence |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No Predicted GO terms available for this sequence |
| InterPro domains | Description | Start | Stop |
|---|---|---|---|
| IPR006906 | Timeless | 45 | 366 |
| No external refs found! |