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  5. YMR190C

YMR190C


Description : RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant [Source:SGD;Acc:S000004802]


Gene families : OG_03_0000205 (OF) Phylogenetic Tree(s): OG0000205_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YMR190C
Cluster HCCA: Cluster_48

Target Alias Description ECC score Gene Family Method Actions
AFR93870 No alias bloom syndrome protein;Helicase conserved C-terminal... 0.06 OF
AFR95257 No alias ATP-dependent DNA helicase;DEAD/DEAH box helicase;RecQ... 0.03 OF
AOA66834 No alias HRDC domain 0.06 OF
CAG78330 No alias Helicase, C-terminal 0.03 OF
CAG78930 No alias DEAD/DEAH box helicase domain 0.05 OF
CBF86151 No alias Putative uncharacterized proteinRecQ helicase MUSN 0.02 OF
EAA34794 No alias RQC domain 0.08 OF
EAL87589 No alias RecQ family helicase MusN 0.08 OF
EAU89723 No alias DNA helicase 0.04 OF
EDO02025 No alias DEAD/DEAH box helicase domain 0.13 OF
EFI26818 No alias ATP-dependent DNA helicase 0.03 OF
EGR52672 No alias HRDC domain 0.11 OF
ESU05747 No alias ATP-dependent DNA helicase RecQ, zinc-binding domain 0.08 OF
KHC82077 No alias RecQ family ATP-dependent DNA helicase;RecQ... 0.06 OF
MGG_05700T0 No alias RecQ helicase MUSN [Source:UniProtKB/TrEMBL;Acc:G4MP38] 0.02 OF
POW03456 No alias DEAD/DEAH box helicase domain 0.01 OF
SPAC2G11.12.1 No alias RecQ type DNA helicase Rqh1 [Source:PomBase;Acc:SPAC2G11.12] 0.09 OF

Type GO Term Name Evidence Source
MF GO:0003676 nucleic acid binding IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0006260 DNA replication IEA Interproscan
BP GO:0006281 DNA repair IEA Interproscan
MF GO:0043138 3'-5' DNA helicase activity IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR032284 RecQ_Zn-bd 1007 1073
IPR011545 DEAD/DEAH_box_helicase_dom 681 850
IPR001650 Helicase_C 890 994
IPR022758 Helicase_Sgs1 1271 1349
IPR018982 RQC_domain 1081 1196
No external refs found!