Description : DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; important for crossover recombination; translation from different start sites produces mitochondrial and nuclear forms; nuclear form is a catalytic inhibitor of telomerase; mitochondrial form involved in DNA repair and recombination; mutations affect Zn, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells [Source:SGD;Acc:S000004526]
Gene families : OG_03_0000319 (OF) Phylogenetic Tree(s): OG0000319_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | HRR: YML061C | |
| Cluster | HCCA: Cluster_37 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| AOA67010 | No alias | DNA helicase Pif1-like | 0.04 | OF | |
| CAG80813 | No alias | DNA helicase Pif1-like | 0.07 | OF | |
| CAG83665 | No alias | DNA helicase Pif1-like | 0.03 | OF | |
| CAG83912 | No alias | DNA helicase Pif1-like | 0.1 | OF | |
| CBF71681 | No alias | helicase | 0.06 | OF | |
| EAA27456 | No alias | DNA helicase Pif1-like | 0.07 | OF | |
| EAL91279 | No alias | mitochondrial DNA helicase (Pif1), putative | 0.09 | OF | |
| EAU90478 | No alias | DNA repair and recombination protein pif1 | 0.04 | OF | |
| EDO00866 | No alias | Zinc finger, CCHC-type | 0.03 | OF | |
| EFI28655 | No alias | DNA repair and recombination protein pif1 | 0.02 | OF | |
| KHC70591 | No alias | ATP-dependent DNA helicase PIF1;PIF1-like helicase | 0.05 | OF | |
| MGG_05212T0 | No alias | Putative uncharacterized protein... | 0.05 | OF | |
| POW07787 | No alias | DNA helicase Pif1-like;Ribonuclease H1, N-terminal | 0.03 | OF | |
| POW13316 | No alias | DNA helicase Pif1-like | 0.04 | OF |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| BP | GO:0000723 | telomere maintenance | IEA | Interproscan |
| MF | GO:0003678 | DNA helicase activity | IEA | Interproscan |
| BP | GO:0006281 | DNA repair | IEA | Interproscan |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No Predicted GO terms available for this sequence |
| No external refs found! |