Description : Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication [Source:SGD;Acc:S000004434]
Gene families : OG_03_0001284 (OF) Phylogenetic Tree(s): OG0001284_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YLR442C | |
Cluster | HCCA: Cluster_63 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AOA70326 | No alias | AAA lid domain | 0.03 | OF | |
CAG80833 | No alias | ATPase, AAA-type, core | 0.04 | OF | |
CAK45318 | No alias | ATPase family associated with various cellular activities (AAA) | 0.02 | OF | |
EAU91735 | No alias | replication control protein 1 | 0.02 | OF | |
EGR50790 | No alias | ATPase, AAA-type, core | 0.02 | OF | |
KHC83088 | No alias | origin recognition complex subunit 1;AAA lid... | 0.12 | OF | |
MGG_05615T0 | No alias | Origin recognition complex subunit 1... | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0003682 | chromatin binding | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
No external refs found! |