YLR398C

Description : Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome [Source:SGD;Acc:S000004390]

Gene families : OG_03_0003577 (OF) Phylogenetic Tree(s): OG0003577_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YLR398C
Cluster	HCCA: Cluster_48

Target	Alias	Description	ECC score	Gene Family Method
AOA67182	No alias	ATP-dependent RNA helicase Ski2, C-terminal	0.1	OF
CAG83924	No alias	ATP-dependent RNA helicase Ski2, C-terminal	0.07	OF
CAG83968	No alias	ATP-dependent RNA helicase Ski2, C-terminal	0.06	OF
CAK97360	No alias	DSHCT (NUC185) domain	0.02	OF
CBF70374	No alias	DEAD/DEAH box RNA helicase	0.02	OF
EAA36252	No alias	DEAD/DEAH box helicase domain	0.02	OF
EAL93295	No alias	DEAD/DEAH box RNA helicase (Ski2), putative	0.07	OF
EFI28708	No alias	translation repressor	0.03	OF
EGR49760	No alias	Ski2, N-terminal domain	0.09	OF
ESU10534	No alias	antiviral helicase SKI2	0.08	OF
KHC70714	No alias	antiviral helicase SKI2;DEAD/DEAH box helicase;Helicase...	0.14	OF
MGG_15042T0	No alias	Putative uncharacterized protein...	0.04	OF
SPCC550.03c.1	No alias	Ski complex RNA helicase Ski2 (predicted)...	0.04	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
MF	GO:0008144	drug binding	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR012961	Ski2_C	1109	1282
IPR001650	Helicase_C	653	768
IPR025696	rRNA_proc-arch_dom	823	1078
IPR040801	Ski2_N	83	215
IPR011545	DEAD/DEAH_box_helicase_dom	333	481

External Links

No external refs found!

YLR398C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation