Description : Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication [Source:SGD;Acc:S000004363]

Gene families : OG_03_0001137 (OF) Phylogenetic Tree(s): OG0001137_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YLR371W
Cluster HCCA: Cluster_56

Target Alias Description ECC score Gene Family Method Actions
AFR96851 No alias rho guanyl-nucleotide exchange factor;RhoGEF... 0.09 OF
AOA68611 No alias Pleckstrin homology domain 5 0.09 OF
CAG83379 No alias Pleckstrin homology domain 5 0.04 OF
CAK39428 No alias CNH domain 0.12 OF
CBF76930 No alias conserved hypothetical protein similar to Rho guanine... 0.11 OF
EAA36572 No alias Pleckstrin homology domain 5 0.09 OF
EAL91744 No alias Rho guanyl nucleotide exchange factor (Rom2), putative 0.13 OF
EAU90407 No alias signal transducer 0.02 OF
EDO00705 No alias Citron homology (CNH) domain 0.13 OF
EED81862 No alias Dbl homology (DH) domain 0.04 OF
EFI27376 No alias RhoGEF Rgf2 0.07 OF
EGR46691 No alias Citron homology (CNH) domain 0.17 OF
EJF59044 No alias RhoGEF domain 0.05 OF
ESU14753 No alias Citron homology (CNH) domain 0.15 OF
KHC81384 No alias hypothetical protein;"Domain found in Dishevelled,... 0.09 OF
MGG_03064T0 No alias Rho1 guanine nucleotide exchange factor 1... 0.05 OF
POV95364 No alias Dbl homology (DH) domain;Citron homology (CNH)... 0.03 OF
SPAC1006.06.1 No alias RhoGEF Rgf2 [Source:PomBase;Acc:SPAC1006.06] 0.12 OF
SPCC645.07.1 No alias RhoGEF for Rho1, Rgf1 [Source:PomBase;Acc:SPCC645.07] 0.17 OF

Type GO Term Name Evidence Source
MF GO:0005085 guanyl-nucleotide exchange factor activity IEA Interproscan
BP GO:0035556 intracellular signal transduction IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR041675 PH_5 881 1011
IPR000591 DEP_dom 432 501
IPR000219 DH-domain 664 844
IPR001180 CNH_dom 1041 1332
No external refs found!