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YLR103C


Description : DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes [Source:SGD;Acc:S000004093]


Gene families : OG_03_0002638 (OF) Phylogenetic Tree(s): OG0002638_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YLR103C
Cluster HCCA: Cluster_37

Target Alias Description ECC score Gene Family Method Actions
AFR95427 No alias cell division control protein 45;CDC45-like protein 0.07 OF
AOA66626 No alias CDC45 family 0.06 OF
CAG82796 No alias CDC45 family 0.09 OF
CAK44141 No alias CDC45-like protein 0.03 OF
CBF88619 No alias DNA replication initiation factor Cdc45 0.05 OF
EAA28219 No alias CDC45 family 0.03 OF
EAL90862 No alias DNA replication initiation factor Cdc45 0.06 OF
EDO00164 No alias CDC45 family 0.03 OF
EED84193 No alias CDC45 family 0.05 OF
EGR51781 No alias CDC45 family 0.03 OF
ESU16198 No alias CDC45 family 0.04 OF
MGG_01549T0 No alias DNA replication initiation factor Cdc45... 0.02 OF

Type GO Term Name Evidence Source
BP GO:0006270 DNA replication initiation IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR003874 CDC45 28 646
No external refs found!