Description : DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes [Source:SGD;Acc:S000004093]
Gene families : OG_03_0002638 (OF) Phylogenetic Tree(s): OG0002638_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YLR103C | |
Cluster | HCCA: Cluster_37 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AFR95427 | No alias | cell division control protein 45;CDC45-like protein | 0.07 | OF | |
AOA66626 | No alias | CDC45 family | 0.06 | OF | |
CAG82796 | No alias | CDC45 family | 0.09 | OF | |
CAK44141 | No alias | CDC45-like protein | 0.03 | OF | |
CBF88619 | No alias | DNA replication initiation factor Cdc45 | 0.05 | OF | |
EAA28219 | No alias | CDC45 family | 0.03 | OF | |
EAL90862 | No alias | DNA replication initiation factor Cdc45 | 0.06 | OF | |
EDO00164 | No alias | CDC45 family | 0.03 | OF | |
EED84193 | No alias | CDC45 family | 0.05 | OF | |
EGR51781 | No alias | CDC45 family | 0.03 | OF | |
ESU16198 | No alias | CDC45 family | 0.04 | OF | |
MGG_01549T0 | No alias | DNA replication initiation factor Cdc45... | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
BP | GO:0006270 | DNA replication initiation | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR003874 | CDC45 | 28 | 646 |
No external refs found! |