Description : Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress [Source:SGD;Acc:S000001121]

Gene families : OG_03_0002651 (OF) Phylogenetic Tree(s): OG0002651_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YHR079C
Cluster HCCA: Cluster_56

Target Alias Description ECC score Gene Family Method Actions
AFR93175 No alias IRE protein kinase;Ribonuclease 2-5A;Protein kinase domain 0.08 OF
AOA68231 No alias Protein kinase domain 0.03 OF
CAG84004 No alias KEN domain 0.07 OF
EDO02347 No alias Protein kinase domain 0.02 OF
EGR51316 No alias Protein kinase domain 0.05 OF
KHC83548 No alias serine/threonine-protein kinase/endoribonuclease... 0.04 OF
MGG_15988T0 No alias IRE protein kinase [Source:UniProtKB/TrEMBL;Acc:G4MME3] 0.05 OF
SPAC167.01.1 No alias serine/threonine protein kinase, sensor for unfolded... 0.08 OF

Type GO Term Name Evidence Source
MF GO:0004540 ribonuclease activity IEA Interproscan
MF GO:0004672 protein kinase activity IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0006397 mRNA processing IEA Interproscan
BP GO:0006468 protein phosphorylation IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR010513 KEN_dom 986 1112
IPR000719 Prot_kinase_dom 676 866
IPR000719 Prot_kinase_dom 894 980
No external refs found!