YGR048W

Description : Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP) [Source:SGD;Acc:S000003280]

Gene families : OG_03_0003281 (OF) Phylogenetic Tree(s): OG0003281_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YGR048W
Cluster	HCCA: Cluster_33

Target	Alias	Description	ECC score	Gene Family Method
CAG80017	No alias	Ubiquitin fusion degradation protein Ufd1-like	0.06	OF
EAA34094	No alias	Ubiquitin fusion degradation protein Ufd1-like	0.02	OF
EAU88478	No alias	ubiquitin fusion degradation protein I	0.05	OF
ESU12327	No alias	Ubiquitin fusion degradation protein Ufd1-like	0.06	OF
KHC81334	No alias	ubiquitin fusion degradation protein 1;Ubiquitin fusion...	0.11	OF
MGG_03175T0	No alias	Ubiquitin fusion degradation protein 1...	0.04	OF

Type	GO Term	Name	Evidence	Source
BP	GO:0006508	proteolysis	None	Extended
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	Interproscan
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009057	macromolecule catabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0019941	modification-dependent protein catabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043632	modification-dependent macromolecule catabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044265	cellular macromolecule catabolic process	None	Extended
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901575	organic substance catabolic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR004854	Ufd1-like	21	199

External Links

No external refs found!

YGR048W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation