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  5. YGL086W

YGL086W


Description : Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability [Source:SGD;Acc:S000003054]


Gene families : OG_03_0004152 (OF) Phylogenetic Tree(s): OG0004152_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood HRR: YGL086W
Cluster HCCA: Cluster_59

Target Alias Description ECC score Gene Family Method Actions
CAK45636 No alias Mitotic checkpoint protein 0.03 OF
EAA28269 No alias Spindle assembly checkpoint component Mad1 0.04 OF
EGR44849 No alias Spindle assembly checkpoint component Mad1 0.05 OF
EJF60921 No alias Mitotic checkpoint protein 0.04 OF
KHC84002 No alias mitotic spindle assembly checkpoint protein MAD1;Mitotic... 0.04 OF
POW04542 No alias Spindle assembly checkpoint component Mad1 0.02 OF
SPBC3D6.04c.1 No alias mitotic spindle checkpoint protein Mad1... 0.02 OF

Type GO Term Name Evidence Source
BP GO:0007094 mitotic spindle assembly checkpoint IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR008672 Mad1 68 744
No external refs found!