YFR010W

Description : Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant [Source:SGD;Acc:S000001906]

Gene families : OG_03_0002011 (OF) Phylogenetic Tree(s): OG0002011_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YFR010W
Cluster	HCCA: Cluster_33

Target	Alias	Description	ECC score	Gene Family Method
AFR96333	No alias	ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin...	0.13	OF
AOA70001	No alias	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	0.04	OF
CAG80532	No alias	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	0.12	OF
CBF78212	No alias	ubiquitin C-terminal hydrolase, putative	0.06	OF
EAA36314	No alias	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	0.14	OF
EAL85801	No alias	ubiquitin C-terminal hydrolase, putative	0.04	OF
EDO02700	No alias	Ubiquitin-like domain	0.08	OF
EFI26871	No alias	ubiquitin carboxyl-terminal hydrolase 6	0.04	OF
EGR49828	No alias	Ubiquitin-like domain	0.18	OF
EJF59278	No alias	Ubiquitin carboxyl-terminal hydrolase	0.03	OF
ESU14355	No alias	ubiquitin carboxyl-terminal hydrolase 6	0.09	OF
KHC82835	No alias	ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin...	0.12	OF
MGG_02970T0	No alias	Ubiquitin carboxyl-terminal hydrolase 6...	0.05	OF
POW04400	No alias	Ubiquitin-like domain;Peptidase C19, ubiquitin...	0.02	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
BP	GO:0006464	cellular protein modification process	None	Extended
BP	GO:0006508	proteolysis	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008234	cysteine-type peptidase activity	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016579	protein deubiquitination	IEA	Interproscan
MF	GO:0016787	hydrolase activity	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
MF	GO:0019783	ubiquitin-like protein-specific protease activity	None	Extended
BP	GO:0036211	protein modification process	None	Extended
MF	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	Interproscan
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044267	cellular protein metabolic process	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0070646	protein modification by small protein removal	None	Extended
BP	GO:0070647	protein modification by small protein conjugation or removal	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0101005	ubiquitinyl hydrolase activity	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR001394	Peptidase_C19_UCH	109	494

External Links

No external refs found!

YFR010W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation