YFR010W


Description : Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant [Source:SGD;Acc:S000001906]


Gene families : OG_03_0002011 (OF) Phylogenetic Tree(s): OG0002011_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YFR010W
Cluster HCCA: Cluster_33

Target Alias Description ECC score Gene Family Method Actions
AFR96333 No alias ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin... 0.13 OF
AOA70001 No alias Peptidase C19, ubiquitin carboxyl-terminal hydrolase 0.04 OF
CAG80532 No alias Peptidase C19, ubiquitin carboxyl-terminal hydrolase 0.12 OF
CBF78212 No alias ubiquitin C-terminal hydrolase, putative 0.06 OF
EAA36314 No alias Peptidase C19, ubiquitin carboxyl-terminal hydrolase 0.14 OF
EAL85801 No alias ubiquitin C-terminal hydrolase, putative 0.04 OF
EDO02700 No alias Ubiquitin-like domain 0.08 OF
EFI26871 No alias ubiquitin carboxyl-terminal hydrolase 6 0.04 OF
EGR49828 No alias Ubiquitin-like domain 0.18 OF
EJF59278 No alias Ubiquitin carboxyl-terminal hydrolase 0.03 OF
ESU14355 No alias ubiquitin carboxyl-terminal hydrolase 6 0.09 OF
KHC82835 No alias ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin... 0.12 OF
MGG_02970T0 No alias Ubiquitin carboxyl-terminal hydrolase 6... 0.05 OF
POW04400 No alias Ubiquitin-like domain;Peptidase C19, ubiquitin... 0.02 OF

Type GO Term Name Evidence Source
BP GO:0016579 protein deubiquitination IEA Interproscan
MF GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001394 Peptidase_C19_UCH 109 494
No external refs found!