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  5. YER125W

YER125W


Description : NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927]


Gene families : OG_03_0001412 (OF) Phylogenetic Tree(s): OG0001412_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood HRR: YER125W
Cluster HCCA: Cluster_34

Target Alias Description ECC score Gene Family Method Actions
AOA67156 No alias HECT domain 0.03 OF
CAK39787 No alias C2 domain 0.04 OF
EAA28350 No alias WW domain 0.03 OF
EDO01234 No alias WW domain 0.02 OF
KHC81871 No alias E3 ubiquitin-protein ligase RSP5;C2 domain;WW... 0.03 OF
MGG_07255T0 No alias E3 ubiquitin-protein ligase hulA... 0.02 OF
POW10061 No alias WW domain;WW domain;HECT domain;C2 domain 0.03 OF
SPAC11G7.02.1 No alias HECT-type ubiquitin-protein ligase E3 Pub1... 0.07 OF
SPBC16E9.11c.1 No alias HECT-type ubiquitin-protein ligase E3 Pub3 (predicted)... 0.02 OF

Type GO Term Name Evidence Source
MF GO:0004842 ubiquitin-protein transferase activity IEA Interproscan
MF GO:0005515 protein binding IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR001202 WW_dom 389 418
IPR001202 WW_dom 333 362
IPR001202 WW_dom 231 260
IPR000008 C2_dom 5 95
IPR000569 HECT_dom 506 807
No external refs found!