YER025W

Description : Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) [Source:SGD;Acc:S000000827]

Gene families : OG_03_0003074 (OF) Phylogenetic Tree(s): OG0003074_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YER025W
Cluster	HCCA: Cluster_54

Target	Alias	Description	ECC score	Gene Family Method
AFR95129	No alias	histone-lysine N-methyltransferase Su(var)3-9;Elongation...	0.13	OF
AOA68359	No alias	Translation initiation factor 2, gamma subunit, C-terminal	0.1	OF
CAG83661	No alias	Translation initiation factor 2, gamma subunit, C-terminal	0.17	OF
CAL00681	No alias	Elongation factor Tu GTP binding domain	0.1	OF
CBF77444	No alias	hypothetical protein similar to translation initiation...	0.07	OF
EAA35230	No alias	Translation elongation factor EFTu-like, domain 2	0.08	OF
EAL90029	No alias	translation initiation factor EF-2 gamma subunit, putative	0.09	OF
EAU87810	No alias	translation initiation factor eIF2 gamma subunit	0.07	OF
EGR50214	No alias	Translation elongation factor EFTu-like, domain 2	0.12	OF
EJF57497	No alias	Elongation factor Tu GTP binding domain	0.08	OF
ESU12989	No alias	eukaryotic translation initiation factor 2 subunit gamma	0.04	OF
KHC75118	No alias	eukaryotic translation initiation factor 2 subunit...	0.1	OF
MGG_01592T0	No alias	Eukaryotic translation initiation factor 2 subunit gamma...	0.1	OF
POW05607	No alias	Transcription factor, GTP-binding domain;Translation...	0.04	OF
SPBC17G9.09.1	No alias	translation initiation factor eIF2 gamma subunit...	0.03	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0001882	nucleoside binding	None	Extended
MF	GO:0001883	purine nucleoside binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003924	GTPase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005525	GTP binding	IEA	Interproscan
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0019001	guanyl nucleotide binding	None	Extended
MF	GO:0032549	ribonucleoside binding	None	Extended
MF	GO:0032550	purine ribonucleoside binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032561	guanyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR015256	TIF2_gsu_C	429	517
IPR004161	EFTu-like_2	335	417
IPR000795	TF_GTP-bd_dom	100	303

External Links

No external refs found!

YER025W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation