Description : DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain (CAD) is phosphorylated at multiple sites by Cdc28p/Clb2p [Source:SGD;Acc:S000002625]

Gene families : OG_03_0003976 (OF) Phylogenetic Tree(s): OG0003976_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YDR217C
Cluster HCCA: Cluster_63

Target Alias Description ECC score Gene Family Method Actions
AOA69348 No alias BRCT domain 0.07 OF
CAG80232 No alias BRCT domain 0.07 OF
CAL00345 No alias BRCA1 C Terminus (BRCT) domain 0.03 OF
EAA31374 No alias BRCT domain 0.07 OF
EAL85904 No alias DNA damage repair protein (Rad9), putative 0.03 OF
ESU11120 No alias BRCT domain 0.06 OF
MGG_12276T0 No alias Putative uncharacterized protein... 0.06 OF

Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001357 BRCT_dom 995 1109
IPR013914 Rad9_Rad53-bd_dom_fun 772 900
No external refs found!