Description : Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins [Source:SGD;Acc:S000002550]

Gene families : OG_03_0000922 (OF) Phylogenetic Tree(s): OG0000922_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YDR143C
Cluster HCCA: Cluster_18

Target Alias Description ECC score Gene Family Method Actions
EAL85252 No alias RING finger protein 0.03 OF
EJF60481 No alias Ring finger domain 0.02 OF
SPBC17D11.02c.1 No alias synviolin family ubiquitin-protein ligase E3, Hrd1... 0.02 OF

Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001841 Znf_RING 250 280
No external refs found!