Description : Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication [Source:SGD;Acc:S000002408]

Gene families : OG_03_0000709 (OF) Phylogenetic Tree(s): OG0000709_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YDR001C
Cluster HCCA: Cluster_45

Target Alias Description ECC score Gene Family Method Actions
AFR93292 No alias alpha,alpha-trehalase;Trehalase;Neutral trehalase Ca2+... 0.02 OF
AOA70049 No alias Glycoside hydrolase, family 37 0.05 OF
CAK43979 No alias Neutral trehalase Ca2+ binding domain 0.04 OF
CBF81508 No alias Neutral trehalase 0.02 OF
EED78320 No alias Glycoside hydrolase, family 37 0.04 OF
EED84284 No alias Glycoside hydrolase, family 37 0.03 OF
KHC71038 No alias neutral trehalase;Neutral trehalase Ca2+ binding domain;Trehalase 0.02 OF
MGG_09471T0 No alias Neutral trehalase [Source:UniProtKB/Swiss-Prot;Acc:O42622] 0.03 OF
POW02420 No alias Glycoside hydrolase, family 37 0.02 OF
SPBC660.07.1 No alias alpha,alpha-trehalase Ntp1 [Source:PomBase;Acc:SPBC660.07] 0.08 OF

Type GO Term Name Evidence Source
MF GO:0004555 alpha,alpha-trehalase activity IEA Interproscan
MF GO:0005509 calcium ion binding IEA Interproscan
CC GO:0005737 cytoplasm IEA Interproscan
BP GO:0005991 trehalose metabolic process IEA Interproscan
BP GO:0005993 trehalose catabolic process IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR011120 Trehalase_Ca-bd 106 135
IPR001661 Glyco_hydro_37 163 721
No external refs found!