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Description : Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000003330]
Sample enrichment: gal, 2h + hu 200 mm,WT (SPM: 0.35, entropy: 3.73, tau: 0.68)