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Expression profile for YJL090C (YJL090C)

Description : DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress [Source:SGD;Acc:S000003626]

Sample enrichment: 0.1 mm CuSO4,WT (SPM: 0.29, entropy: 3.76, tau: 0.58)
Perturbation specificity: Gal (SPM: 0.45, entropy: 3.08, tau: 0.44)