YJL090C


Description : DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress [Source:SGD;Acc:S000003626]


Gene families : OG_03_0002017 (OF) Phylogenetic Tree(s): OG0002017_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YJL090C
Cluster HCCA: Cluster_23

Target Alias Description ECC score Gene Family Method Actions
CAK42047 No alias twin BRCT domain 0.01 OF
CBF71683 No alias BRCT domain protein 0.03 OF
EAL91278 No alias BRCT domain protein 0.04 OF
EED80012 No alias BRCT domain 0.03 OF
EGR50315 No alias BRCT domain 0.02 OF
ESU08202 No alias BRCT domain 0.02 OF
SPAC23C4.18c.1 No alias BRCT domain protein Rad4 [Source:PomBase;Acc:SPAC23C4.18c] 0.02 OF

Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001357 BRCT_dom 324 412
IPR001357 BRCT_dom 111 206
IPR001357 BRCT_dom 1 66
No external refs found!