Description : DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress [Source:SGD;Acc:S000003626]
Gene families : OG_03_0002017 (OF) Phylogenetic Tree(s): OG0002017_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YJL090C | |
Cluster | HCCA: Cluster_23 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
CAK42047 | No alias | twin BRCT domain | 0.01 | OF | |
CBF71683 | No alias | BRCT domain protein | 0.03 | OF | |
EAL91278 | No alias | BRCT domain protein | 0.04 | OF | |
EED80012 | No alias | BRCT domain | 0.03 | OF | |
EGR50315 | No alias | BRCT domain | 0.02 | OF | |
ESU08202 | No alias | BRCT domain | 0.02 | OF | |
SPAC23C4.18c.1 | No alias | BRCT domain protein Rad4 [Source:PomBase;Acc:SPAC23C4.18c] | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
No external refs found! |