GO:0000213: tRNA-intron endonuclease activity (Molecular function)

"Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]


There are 37 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_68 Aspergillus nidulans 1.59 % 0.011926 0.032433
Cluster_26 Aspergillus niger 0.83 % 0.008607 0.033917
Cluster_53 Candida albicans 1.35 % 0.023022 0.04566
Cluster_86 Puccinia striiformis 1.61 % 0.008201 0.041004
Cluster_40 Trichoderma reesei 1.67 % 0.013123 0.038887
Cluster_66 Sclerotinia sclerotiorum 1.49 % 0.013127 0.039791
Sequences (37) (download table)
YAR008W No alias Saccharomyces cerevisiae Subunit of the tRNA splicing endonuclease; tRNA splicing...
YLR105C No alias Saccharomyces cerevisiae Subunit of the tRNA splicing endonuclease; tRNA splicing...
EED48035 No alias Aspergillus flavus tRNA-splicing endonuclease subunit Sen2, putative
EED50469 No alias Aspergillus flavus tRNA-splicing endonuclease subunit sen34
EAL85905 No alias Aspergillus fumigatus tRNA-splicing endonuclease subunit Sen2, putative
EAL91496 No alias Aspergillus fumigatus tRNA-splicing endonuclease subunit sen34
CBF74219 No alias Aspergillus nidulans DNA damage repair protein
CBF90007 No alias Aspergillus nidulans tRNA-splicing endonuclease subunit sen34
CAL00346 No alias Aspergillus niger tRNA intron endonuclease, catalytic C-terminal domain
KHC77315 No alias Candida albicans tRNA-intron endonuclease;"tRNA intron endonuclease,...
KHC81608 No alias Candida albicans tRNA-intron endonuclease;"tRNA intron endonuclease,...
EAU88239 No alias Coprinopsis cinerea tRNA intron endonuclease, catalytic domain-like
EAU90207 No alias Coprinopsis cinerea tRNA-intron endonuclease
AFR93719 No alias Cryptococcus neoformans tRNA-splicing endonuclease subunit Sen2;tRNA intron...
AFR97869 No alias Cryptococcus neoformans tRNA-splicing endonuclease subunit Sen34;tRNA intron...
ESU08844 No alias Fusarium graminearum tRNA intron endonuclease, catalytic domain-like
ESU11989 No alias Fusarium graminearum tRNA intron endonuclease, catalytic domain-like
AOA66995 No alias Komagataella phaffii tRNA intron endonuclease, catalytic domain-like
AOA67122 No alias Komagataella phaffii tRNA intron endonuclease, catalytic domain-like
EAA31786 No alias Neurospora crassa tRNA intron endonuclease, catalytic domain-like
EAA33466 No alias Neurospora crassa tRNA intron endonuclease, catalytic domain-like
EED77790 No alias Postia placenta tRNA intron endonuclease, catalytic domain-like
EED80587 No alias Postia placenta tRNA intron endonuclease, catalytic domain-like
EED81709 No alias Postia placenta tRNA intron endonuclease, catalytic domain-like
EED85613 No alias Postia placenta tRNA intron endonuclease, catalytic domain-like
POW00644 No alias Puccinia striiformis tRNA intron endonuclease, catalytic domain-like
POW01605 No alias Puccinia striiformis tRNA intron endonuclease, catalytic domain-like
MGG_07082T0 No alias Pyricularia oryzae tRNA-splicing endonuclease subunit sen34...
MGG_15480T0 No alias Pyricularia oryzae Putative uncharacterized protein...
CAG80118 No alias Yarrowia lipolytica tRNA intron endonuclease, catalytic domain-like

InterPro Domains
Label Description Count Sequence count Species count
IPR006677 tRNA_intron_Endonuc_cat-like 37 37 18
IPR001357 BRCT_dom 1 1 1
IPR013914 Rad9_Rad53-bd_dom_fun 1 1 1

GO Terms
Label Name Description Sequence count Species count
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation "Splicing of tRNA substrates via recognition of the folded RNA structure... 37 18
GO:0004549 tRNA-specific ribonuclease activity "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah] 37 18
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by... 37 18
GO:0004540 ribonuclease activity "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA."... 37 18
GO:0140101 catalytic activity, acting on a tRNA "Catalytic activity that acts to modify a tRNA."... 37 18
GO:0004521 endoribonuclease activity "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by... 37 18
GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters "Catalysis of the hydrolysis of ester linkages within nucleic acids by... 37 18
GO:0004518 nuclease activity "Catalysis of the hydrolysis of ester linkages within nucleic acids."... 37 18
GO:0140098 catalytic activity, acting on RNA "Catalytic activity that acts to modify RNA."... 37 18
GO:0004519 endonuclease activity "Catalysis of the hydrolysis of ester linkages within nucleic acids by... 37 18
GO:0016788 hydrolase activity, acting on ester bonds "Catalysis of the hydrolysis of any ester bond." [GOC:jl] 37 18
GO:0003824 catalytic activity "Catalysis of a biochemical reaction at physiological temperatures. In... 37 18
GO:0016787 hydrolase activity "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C,... 37 18
GO:0003674 molecular_function "A molecular process that can be carried out by the action of a single... 37 18
GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation "Splicing of RNA via recognition of the folded RNA structure that brings the... 37 18
GO:0008033 tRNA processing "The process in which a pre-tRNA molecule is converted to a mature tRNA,... 37 18
GO:0008380 RNA splicing "The process of removing sections of the primary RNA transcript to remove... 37 18
GO:0006399 tRNA metabolic process "The chemical reactions and pathways involving tRNA, transfer RNA, a class... 37 18
GO:0034470 ncRNA processing "Any process that results in the conversion of one or more primary... 37 18
GO:0006396 RNA processing "Any process involved in the conversion of one or more primary RNA... 37 18
GO:0034660 ncRNA metabolic process "The chemical reactions and pathways involving non-coding RNA transcripts... 37 18
GO:0016070 RNA metabolic process "The cellular chemical reactions and pathways involving RNA, ribonucleic... 37 18
GO:0090304 nucleic acid metabolic process "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] 37 18
GO:0006139 nucleobase-containing compound metabolic process "Any cellular metabolic process involving nucleobases, nucleosides,... 37 18
GO:0043170 macromolecule metabolic process "The chemical reactions and pathways involving macromolecules, any molecule... 37 18
GO:0006725 cellular aromatic compound metabolic process "The chemical reactions and pathways involving aromatic compounds, any... 37 18
GO:0034641 cellular nitrogen compound metabolic process "The chemical reactions and pathways involving various organic and inorganic... 37 18
GO:0044238 primary metabolic process "The chemical reactions and pathways involving those compounds which are... 37 18
GO:0046483 heterocycle metabolic process "The chemical reactions and pathways involving heterocyclic compounds, those... 37 18
GO:1901360 organic cyclic compound metabolic process "The chemical reactions and pathways involving organic cyclic compound."... 37 18
GO:0071704 organic substance metabolic process "The chemical reactions and pathways involving an organic substance, any... 37 18
GO:0044237 cellular metabolic process "The chemical reactions and pathways by which individual cells transform... 37 18
GO:0006807 nitrogen compound metabolic process "The chemical reactions and pathways involving organic or inorganic... 37 18
GO:0008152 metabolic process "The chemical reactions and pathways, including anabolism and catabolism, by... 37 18
GO:0009987 cellular process "Any process that is carried out at the cellular level, but not necessarily... 37 18
GO:0008150 biological_process "A biological process represents a specific objective that the organism is... 37 18

Family Terms
Label Sequence count Species count
OG_03_0001830 19 18
OG_03_0002113 18 17