Description : Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication [Source:SGD;Acc:S000002347]
Gene families : OG_03_0000082 (OF) Phylogenetic Tree(s): OG0000082_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YDL188C | |
Cluster | HCCA: Cluster_46 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
CAK48275 | No alias | Calcineurin-like phosphoesterase | 0.06 | OF | |
EAA32582 | No alias | Calcineurin-like phosphoesterase domain, ApaH type | 0.02 | OF | |
EDN98615 | No alias | Calcineurin-like phosphoesterase domain, ApaH type | 0.02 | OF | |
EGR51741 | No alias | Calcineurin-like phosphoesterase domain, ApaH type | 0.04 | OF | |
ESU16445 | No alias | serine/threonine-protein phosphatase PP2A catalytic subunit | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0016787 | hydrolase activity | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR004843 | Calcineurin-like_PHP_ApaH | 119 | 310 |
No external refs found! |