Description : Nuclear protein with a role in protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; DNA-binding protein with preference for UV-damaged DNA; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions [Source:SGD;Acc:S000002315]
Gene families : OG_03_0003988 (OF) Phylogenetic Tree(s): OG0003988_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YDL156W | |
Cluster | HCCA: Cluster_23 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AFR96900 | No alias | WD-repeat protein | 0.03 | OF | |
CAG78531 | No alias | WD40 repeat | 0.04 | OF | |
EGR48492 | No alias | WD40 repeat | 0.03 | OF | |
KHC71811 | No alias | WD repeat-containing protein;"WD domain, G-beta repeat" | 0.04 | OF | |
POW00653 | No alias | hypothetical protein | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0005515 | protein binding | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR001680 | WD40_repeat | 336 | 362 |
No external refs found! |