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YPL006W


Description : Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p [Source:SGD;Acc:S000005927]


Gene families : OG_03_0001922 (OF) Phylogenetic Tree(s): OG0001922_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YPL006W
Cluster HCCA: Cluster_34

Target Alias Description ECC score Gene Family Method Actions
AOA66745 No alias Sterol-sensing domain 0.05 OF
CAK48400 No alias Niemann-Pick C1 N terminus 0.02 OF
EAL88849 No alias patched sphingolipid transporter (Ncr1), putative 0.02 OF
EDN99368 No alias Protein patched/dispatched 0.04 OF
KHC84157 No alias niemann-Pick C1 protein;Patched family;Sterol-sensing... 0.03 OF
MGG_00819T0 No alias Niemann-Pick C1 protein [Source:UniProtKB/TrEMBL;Acc:G4NE97] 0.02 OF

Type GO Term Name Evidence Source
CC GO:0016021 integral component of membrane IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR003392 Ptc/Disp 372 1156
IPR032190 NPC1_N 21 257
No external refs found!