Description : Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS [Source:SGD;Acc:S000005648]
Gene families : OG_03_0002187 (OF) Phylogenetic Tree(s): OG0002187_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YOR122C | |
Cluster | HCCA: Cluster_24 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
EAL84453 | No alias | profilin Pfy1, putative | 0.02 | OF | |
EDN98219 | No alias | Profilin | 0.03 | OF | |
EGR52025 | No alias | Profilin | 0.01 | OF | |
KHC83554 | No alias | profilin;Profilin | 0.02 | OF | |
POW02490 | No alias | Profilin | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR005455 | PFN | 1 | 126 |
No external refs found! |