YOR011W

Description : Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication [Source:SGD;Acc:S000005537]

Gene families : OG_03_0000022 (OF) Phylogenetic Tree(s): OG0000022_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YOR011W
Cluster	HCCA: Cluster_4

Target	Alias	Description	ECC score	Gene Family Method
AFR95261	No alias	ATP-binding cassette transporter;ABC...	0.01	OF
AFR98586	No alias	ABC transporter PMR5;ABC-2 type transporter;CDR ABC transporter	0.02	OF
CBF79672	No alias	ABC transporter protein	0.02	OF
EED77030	No alias	ABC-2 type transporter	0.02	OF
ESU13641	No alias	ABC transporter-like	0.03	OF
KHC77632	No alias	opaque-specific ABC transporter CDR3;ABC-transporter...	0.02	OF
MGG_13624T0	No alias	ABC transporter CDR4 [Source:UniProtKB/TrEMBL;Acc:G4N9L5]	0.02	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005215	transporter activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006810	transport	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0015399	primary active transmembrane transporter activity	None	Extended
CC	GO:0016020	membrane	IEA	Interproscan
CC	GO:0016021	integral component of membrane	IEA	Interproscan
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	IEA	Interproscan
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0022804	active transmembrane transporter activity	None	Extended
MF	GO:0022857	transmembrane transporter activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
CC	GO:0031224	intrinsic component of membrane	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042626	ATPase-coupled transmembrane transporter activity	IEA	Interproscan
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0055085	transmembrane transport	IEA	Interproscan
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR013525	ABC_2_trans	1062	1273
IPR013525	ABC_2_trans	370	579
IPR010929	PDR_CDR_ABC	591	668
IPR003439	ABC_transporter-like	49	199
IPR003439	ABC_transporter-like	776	906

External Links

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YOR011W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation