Description : Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact [Source:SGD;Acc:S000004537]

Gene families : OG_03_0000772 (OF) Phylogenetic Tree(s): OG0000772_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YML072C
Cluster HCCA: Cluster_8

Target Alias Description ECC score Gene Family Method Actions
AFR98020 No alias transmembrane protein;C2 domain 0.05 OF
AGV14731 No alias transmembrane protein;C2 domain 0.05 OF
CAG80228 No alias C2 domain 0.05 OF
KHC83091 No alias hypothetical protein;C2 domain 0.11 OF
KHC83812 No alias hypothetical protein;C2 domain 0.05 OF
MGG_09947T0 No alias Tricalbin-1 [Source:UniProtKB/TrEMBL;Acc:G4MRL6] 0.03 OF
POW17974 No alias C2 domain 0.03 OF
SPAPYUK71.03c.1 No alias synaptotagmin family C2 domain protein, Syn1... 0.06 OF
SPCC962.01.1 No alias C2 domain endoplasmic reticulum membrane organization... 0.03 OF

Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR000008 C2_dom 1134 1231
IPR000008 C2_dom 666 755
IPR000008 C2_dom 492 592
IPR000008 C2_dom 816 897
IPR000008 C2_dom 1434 1506
No external refs found!