Description : Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers [Source:SGD;Acc:S000004410]
Gene families : OG_03_0003337 (OF) Phylogenetic Tree(s): OG0003337_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YLR418C | |
Cluster | HCCA: Cluster_46 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AFR95537 | No alias | parafibromin;RNA pol II accessory factor, Cdc73 family,... | 0.02 | OF | |
AOA67696 | No alias | Cell division control protein 73, C-terminal | 0.04 | OF | |
CAG83675 | No alias | Cell division control protein 73, C-terminal | 0.05 | OF | |
EGR52656 | No alias | Cell division control protein 73, C-terminal | 0.03 | OF | |
ESA42870 | No alias | Cell division control protein 73, C-terminal | 0.04 | OF | |
ESU12296 | No alias | Cell division control protein 73, C-terminal | 0.08 | OF | |
KHC83073 | No alias | parafibromin;"RNA pol II accessory factor, Cdc73 family,... | 0.03 | OF | |
MGG_15720T0 | No alias | Putative uncharacterized protein... | 0.02 | OF | |
POW16255 | No alias | Cell division control protein 73, C-terminal | 0.02 | OF | |
SPBC17G9.02c.1 | No alias | RNA polymerase II accessory factor, Cdc73 family... | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR031336 | CDC73_C | 235 | 385 |
No external refs found! |