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  5. YBR140C

YBR140C


Description : GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis [Source:SGD;Acc:S000000344]


Gene families : OG_03_0004712 (OF) Phylogenetic Tree(s): OG0004712_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YBR140C
Cluster HCCA: Cluster_12

Target Alias Description ECC score Gene Family Method Actions
AFR96115 No alias neurofibromin 1;GTPase-activator protein for Ras-like... 0.14 OF
AOA68555 No alias Ras GTPase-activating domain 0.13 OF
CAG82841 No alias Ras GTPase-activating domain 0.07 OF
EAA27028 No alias Ras GTPase-activating domain 0.17 OF
EDN98682 No alias Ras GTPase-activating domain 0.11 OF
EFI27794 No alias CRAL-TRIO lipid binding domainRas GTPase-activating domain 0.13 OF
EGR44283 No alias Ras GTPase-activating domain 0.11 OF
EJF62265 No alias GTPase-activator protein for Ras-like GTPase 0.07 OF
ESU18077 No alias CRAL-TRIO lipid binding domain 0.03 OF
KHC83982 No alias hypothetical protein;GTPase-activator protein for Ras-like GTPase 0.17 OF
POW02576 No alias Ras GTPase-activating domain;CRAL-TRIO lipid binding domain 0.06 OF

Type GO Term Name Evidence Source
BP GO:0043087 regulation of GTPase activity IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR001936 RasGAP_dom 1731 1796
IPR001936 RasGAP_dom 1803 1898
No external refs found!